Factual error: The portrayal of Sarah's type-1 diabetes is loaded with inaccuracies. We saw her eating pizza the previous evening and along with this any sensible diabetic would have injected herself with enough insulin to last through the night, to cope with the sugars in the food she'd eaten. But in the panic room just a few hours later, she apparently needs another dose - wrong. If her condition was due to stress, she would have needed sugar or a glycogen injection, not insulin. In response Meg searches for sugary food to give Sarah. That's correct, but next thing Meg wants to inject Sarah with insulin, which would kill any diabetic in such a state. Finally, when becoming hypoglycemic Sarah thrashes about, apparently having an epileptic fit instead of what would really happen - she would just become very sleepy, lose consciousness and go into a coma. All this demonizes diabetes into a convenient scary plot device but in reality the condition is quite mundane - typical Hollywood.
Factual error: After the intruders flood the panic room with propane, Jody Foster's character gets a lighter and ignites the propane causing it to burn along the ceiling. This would be impossible as propane is heavier than air and would sink to the floor rather than rise up to the ceiling. Lighting a flame in that room should have caused anyone in the room and on the floor to be engulfed in flames almost instantly.
Meg: Open the door so I can give her the shot.
Burnham: If we open the door you'll shoot us.
Meg: So give her the shot yourself.
Trivia: The shot of Meg turning on the security screens took 57 takes before director David Fincher was happy.
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