E-I-E-I-(Annoyed Grunt) - S11-E5
Plot hole: When the Simpsons run away from the duel, they go to Homer's childhood farmhouse. But Homer and Grandpa burned the farmhouse down in the episode "Grandpa vs. Sexual Inadequacy".
E-I-E-I-(Annoyed Grunt) - S11-E5
Revealing mistake: After Lisa says "For a product that's evil and deadly" while standing in front of the tomacco stand, there's a duplicate Lisa behind her that stands still while she moves, giving Lisa the appearance of having two heads. It looks like the animators made a mistake while trying to animate Lisa.
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
Xofer