Continuity mistake: The sketch that Brainy shows to Winn is meant to be his original sketch that he drew in the previous episode, hence why Winn is so shocked he's somehow got it. But it's slightly different from what we actually saw him draw at the time.
Continuity mistake: The shield design that Winn sketches on the paper changes between him starting to draw, and him showing it to his friend a second later.
Shelter from the Storm - S3-E18
Continuity mistake: When Winn and Brainy hug, Winn starts the hug with one arm high and one lower, towards Brainy's waist. The shot cuts and both his arms are up and in the centre of his body.
In Search of Lost Time - S3-E15
Continuity mistake: When Samantha sees the surveillance video of her transformation into Reign, which was triggered by Lena provoking her, their dialogue is slightly, but very distinctly, different than it was a few minutes earlier. (00:20:15 - 00:25:25)
Continuity mistake: As Kenny is about to sit down opposite to Kara, the juice on his tray is lying down on it. Next shot it is standing up.
Answer: Yes, s02e22. As Kara leaves her office, she said "go get them, Supergirl" to herself. After season 1, the show switched from a CBS production to a CW production and filming moved from L.A. to Vancouver. Flockhart isn't really a fan of traveling to shoot, and didn't want to be away from her family for so long.
Bishop73