Audio problem: In the first cut scene where Leon talks to Hunnigan he's saying "I thought you'd be a little longer" instead of "I thought you'd be a little older".
Continuity mistake: During the ingame cutscenes, Leon will always have his starting pistol equipped regardless of whether you sell it or have a different weapon equipped.
Trivia: The knife Leon throws when he rescues Ada at the end of the game was Krauser's knife; the same knife he picked up after their first encounter.
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