Continuity mistake: After Leon beats Bitores Mendez and takes his fake eye, you will notice if you look closely at his corpse that his fake eye is still in his head.
Bug: There are certain parts of the game where you can play with the camera. In one of them, you can see through the Merchant's insides and you can see he's truly infected with Las Plagas! Watching him like this is really hilarious.
Continuity mistake: During the ingame cutscenes, Leon will always have his starting pistol equipped regardless of whether you sell it or have a different weapon equipped.
Trivia: After leaving the main menu of RE4 for about 20 seconds, the trailer for the game comes up. During the course of the trailer, there is a short scene of Ashley putting her head in her arms. This is a reverse of a cut scene in the game where you rescue her after fighting the Iron Maiden, in which she looks up to see Leon.
Trivia: The knife Leon throws when he rescues Ada at the end of the game was Krauser's knife; the same knife he picked up after their first encounter.
Trivia: The tactical vest you can buy from the merchant is exactly the same as the STARS jackets worn by the main characters in the Remake of the original Resident Evil for the gamecube.
