Trivia: If the player goes to a certain cliffside overlooking the El Gordo Lighthouse at 11pm, the ghost of Jolene Cranley-Evans, the murdered wife of politician Jock Cranley can be seen. The story is that she was pushed off the cliff by her husband, but her death was later declared as accidental. The name "Jock" can be seen written in blood on the rock Jolene hovers over, accusing him of killing her. The ghost will disappear if the player approaches it, but can be viewed through a sniper rifle scope.
Trivia: There is a secret boss fight that can be unlocked. This can be only unlocked if the player has 100% completed the game, completed the Strangers and Freaks mission The Last One, and collected all 27 peyote plants, as well as collected all 7 golden peyotes which can be found during either foggy or snowy weather. Once all of these requirements have been achieved, the player will then enter a hallucination where they become Bigfoot, and can engage in combat with a beast.
Trivia: In the rural outback area of Los Santos, players can stumble across a scenario in which numerous trucks are parked in a circle, filled with dead bodies and injured survivors in a drug deal gone wrong. The player can then take the money from the deal, but if they do so, two trucks will chase after them and start shooting. This is a reference to the movie No Country for Old Men, in which Llewelyn Moss comes across a drug deal gone wrong, and takes a briefcase of money used for the drug deal and is then pursued afterwards.
Trivia: During a specific time in the day, players can come across a scenario on a cliff in which a car is parked near the edge, and police cars are parked not far behind, cornering the car. The car will then drive off the edge of the cliff and explode when landing. This is a reference to the ending scene of Thelma and Louise, in which the exact same scenario plays out. The two main characters are cornered by police and drive off the edge of a cliff to escape them.
Trivia: Marriage Counselling: When Michael catches his wife sleeping with the tennis coach, he chases him to what he believes is the tennis coach's house, unaware that it actually belongs to Martin Madrazo's girlfriend. Michael then attaches a rope to the foundation poles of the house and drives away, causing the house to collapse. This is a reference to a scene from Lethal Weapon 2, in which Riggs tears down a house using the exact same method.
Trivia: Lindsay Lohan filed a lawsuit against Rockstar, alleging that her likeness was used for the character Lacey Jones without her permission. The lawsuit was dismissed.