Continuity mistake: When Tom the Minion dressed as a maid is hoovering, he answers the front door by opening it towards him as does the minion who looks out of the door after Tom has been taken. In the scene with Gru sat on the steps in the rain, sad that Lucy is off to Australia, Agnes comes out with an umbrella, but now the door opens outwards.
Continuity mistake: In the scene where Gru first meets Lucy Wilde, Gru takes out his freeze ray and fires it at Lucy. Lucy stops the freeze with a flame gun thing and then she walks over to him and tazes him. Gru then drops the freeze ray, but it disappears when she goes to put Gru in the boot of her car. (00:08:30)
Continuity mistake: As soon as Eduardo finishes activating the floor key pad, he is shown standing half way between the start and the end of the floor key pad. Next shot, he is suddenly a few steps away from the end of the pad. (01:03:45)
Audio problem: When they scream at the cupcake shop, Gru sounds like he's behind the glass dome, while Lucy gives off a regular scream. But as we can see, Lucy is behind the dome, making a silly face, not Gru.
Continuity mistake: The Mexican flag on El Macho's chest vanishes after the bakery scene. (00:27:30 - 01:06:15)
Other mistake: In the cupcake shop, Lucy crushes several cupcakes. These cupcakes have icing on them. But no icing goes on Lucy's hands at all. (00:24:35)
Continuity mistake: When the Minion dressed as a maid answers the door, there is nothing next to it. When the shot returns to the door after the Minion has been taken, a umbrella and a holder for the umbrella have suddenly appeared. (00:21:50)
Continuity mistake: After watching El macho activate the dance floor key to the lift, Gru then does the same thing. During the first attempt, Gru spills guacamole on the floor, his nacho hat gets sliced in half and more guacamole falls. He then throws the nacho hat to one side and tries again. But in the shot from above the guacamole on the floor has vanished. (01:04:10)
Audio problem: As Gru attempts the dance floor key, some of the guacamole from his nacho hat falls out of the hat and lands on one of the keys which then triggers one of the sound effects. An axe then chops off the rear end of his nacho hat and lands on the part of the dance floor behind him, but no sound effect is made from the floor. (01:04:05)
Factual error: In the scene where Kevin is floating, eating a banana just before he is converted in a monster, the water begins to spin in a clockwise direction, but Kevin spins in the opposite direction. He should spin in the same direction as the water. (01:02:45)
Plot hole: The rocket is launched with Gru and Lucy attached to it. All of the minions are around them at El Macho's lair at this point. Considering a rocket travels at several hundred miles per hour, when they jump off it almost a minute later they should be several miles away at the very least, but three Minions appear on a boat shortly after. There is no way the three Minions could have reached Gru and Lucy all the way from the lair in that short time. (01:22:05 - 01:23:25)
Suggested correction: Actually, earlier on in the scene, Gru enters El Macho's lair with only two of his remaining minions, despite there being much more that didn't go for the Ice Cream Truck. Therefore, the 3 minions could have been in Gru's basement the whole time. The real problem is, how would they know to go to the volcano?
Plot hole: If the AVL was around during the events of the first film and aware of the moon heist then what was this organization doing while both Gru and Vector were doing their dastardly deeds?
Suggested correction: The AVL probably initiated an investigation regarding the moon's disappearance, but they wouldn't know where to look first. And it all happened very quickly, the moon was only returned to its original spot later on the same day, so they wouldn't need to continue with the case and could disregard it.
Continuity mistake: One of the minions is shown dressed as a maid hoovering the floor. The hoover continues to move along the floor after the minion answers the door. The hoover is shown moving past the door. But when the next minion is shown, the hoover is now shown only just going past the door. (00:21:45)
Continuity mistake: El Macho says that the volcano he was going to launch Lucy into was the same volcano he faked his death in earlier, but his volcano was in a large landscape, while the volcano Lucy and Gru went to was on a little island. (01:19:35)
Continuity mistake: When Gru is attempting to unlock the floor key pad, he triggers an incorrect key and some fire is blown at him. Some smoke is left all over his face. Gru triggers another incorrect key and some darts are launched at him. The smoke is still there, but as he falls over, most of the smoke on his face has gone. The smoke on his right cheek is still there, but has still vanished from his face. (01:04:20)
Suggested correction: I watched the scene carefully. The smoke stains stay there the entire time. When he falls they are perhaps a bit fainter, but still there. When he walks into the elevator and turns toward the camera is very hard to say if all the stains are there or not due his wide smile, and that's only if you pause it.
Continuity mistake: When Gru follows Eduardo through the corridors, he stumbles to find him dancing along a floor key pad to unlock the lift. It is also shown that if a key is pushed incorrectly, the key turns red and a weapon is launched at the person on the key pad. When he begins to activate the key pad, the first key he steps on is the key second to the left on the first row and continues the rest of the pattern. Gru then attempts to do the exact same sequence. The first key he steps on is the key second to the left on the second row, despite the fact that Eduardo actually triggered the first sound effect with the key on the first row, second to the left. Despite this, the sound effect is still correctly triggered. (01:03:40)
Other mistake: As Eduardo goes to leave the cupcake shop, Gru believes he could be El Macho and Eduardo leaves. Gru tells Lucy about El Macho for about 90 seconds, then Eduardo is seen from outside the cake shop window only just about to go up the escalator, when the distance between the shop and escalator is only a few meters. (00:27:55 - 00:29:25)
Continuity mistake: When the elevator door opens to show El Macho's lair, Gru walks out and there is no-one in sight. A few shots later, El Macho has suddenly appeared behind Gru. There was no space behind Gru that El Macho could have hid behind. (01:06:00)
Continuity mistake: When Doctor Nefario is having a send off, he begins to blast off in his scooter very slowly. The shot after he says "This may take a while", the Minions begin to leave the area, yet in the next shot, the other Minions have vanished completely. There was nowhere near any time for them to have left the area that quickly. (00:21:10)