Will Graham: I thought you might be curious to see if you're smarter than the person I'm looking for.
Hannibal Lecktor: Then, by implication, you think you're smarter than me, since it was you who caught me.
Will Graham: No. I know that I'm not smarter than you.
Hannibal Lecktor: Then how did you catch me?
Will Graham: You had disadvantages.
Hannibal Lecktor: What disadvantages?
Will Graham: You're insane.
When William Petersen is talking to his kid in the supermarket, the cereal boxes behind him on the shelves change between two shots. The items behind Kevin also change during the scene.
In the final confrontation between Dollarhyde and Graham, Tom Noonan had to lie in a pool of stage blood for several hours as the crew worked on other shots. After all this time, the stage blood dried into a thick, cement-like adhesive that all but fused Noonan to the carpet.