Plot hole: On the doors inside the white dome, and on the elevator door, it is marked "Vapor Lock." This is impossible due to the mine shaft opening. It can't be vapor locked when there's an opening. (00:35:00)
Plot hole: Because humans have a layer of subcutaneous fat under the skin, the bug that travels under Harry's skin would have caused not only significant damage but an amazing amount of pain while moving around. There would have also been severe internal damage caused by the bug if it traveled into his colon where they ended up removing it from.