Trivia: After 13 years and 26 films, this is the first movie in the Marvel Cinematic Universe to receive a "rotten" rating from Rotten Tomatoes upon release. This is somewhat ironic given that there were reports that Marvel considered it the best film they had made yet, and Marvel Studios President Kevin Feige felt it could be a nominee for Best Picture at the Oscars, particularly as its director Chloé Zhao had recently won the Best Director Oscar for Nomadland, which also won Best Picture.
Trivia: Cary Joji Fukunaga is the first American to direct an official Bond movie.
Trivia: The scene with Jill eating Wesker's sandwich and saying "It's Jill's sandwich now!" (although saying it quickly in such a way that you can't hear the "s" and it sounds more like "It's Jill sandwich now!") is a reference to an infamous moment in the original video game. In the game, Jill is almost crushed by a booby-trap, and the character Barry says she was "almost a Jill sandwich!" The poor dialogue and terrible delivery by the voice actor ended up making the moment a meme many years later.