Continuity mistake: In the title sequence a Rube Goldberg machine can be seen. The error can be seen by watching the four revolvers rotating and then a single revolver firing. When you look at all four revolvers, there are hand grips in each one, but in the closeup shot of one actually firing, the hand grip is empty. You can't see it later than S5E18 because they decided to delete the frames when you can see all four revolvers, and left only closeups.
Starring: Lucy Liu, Aidan Quinn, Jonny Lee Miller, Jon Michael Hill
Character mistake: They are in the interrogation room questioning the fiancé of the scientist Natasha when the captain says, "the blood we found at the scene of your fiance's murder, it didn't belong to Bobby Cordero." The characters name was Benny Cordero, which the captain says correctly a few lines later. (00:33:25)
Sherlock Holmes: If you eliminate the impossible, whatever remains, however improbable, is the truth.
Trivia: Sherlock's brother Mycroft has an international franchise of restaurants called Diogenes. This is a reference to the Diogenes Club, the gentleman's club Mycroft co-founded in the Holmes short stories.
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Chosen answer: M broke into the brownstone and left a note. Holmes deduced he was staying at a high-class hotel from the soap scent on the note, and gave a picture from a hidden camera to his "irregulars" on the street to stake out hotels. One of them saw him, so Holmes followed him to his next intended victim and knocked him unconscious with a baton.