Continuity mistake: In the flashback to 1228, Nick's just-awakened sister Fleur has her hair down over her ears, and is wearing a white night dress that covers her to the neck. Cut to a close-up and her hair is pulled back to reveal pierced earrings (unlikely in 1228, and did she sleep with them on?), and she's suddenly in a bare-shouldered gown instead of her night dress.
Continuity mistake: Nick and Schanke are interrogating a murder suspect and disagreeing about whether or not she did the deed. They leave the interview room together, and Nick's hair completely changes styles as he walks out of the room. On the inside of the door, it's combed down over his forehead and rather "fluffy." The minute he exits on the other side of the door, it's brushed back and slicked down.
Continuity mistake: When Sean sneaks back into the night club owner's office, we can see as he enters that there is no one in the left-hand side of the room. Yet, as Sean sits down at the desk, Walken somehow emerges from the left corner, which we have just seen was empty a moment before.
Continuity mistake: The flashbacks here contradict series canon. Nick's victim, Amaya, is shown to have been bitten (by him) several times. In every other instance, unless he had multiple captive ladies to "sip" from, Nick's bite was fatal in one go. In fact, it was a major recurring plot point that Nick "couldn't stop."
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Continuity mistake: The godfather's thugs storm Nick's loft and riddle him with bullets. We actually see the bullets coming out of his back, leaving holes in the back of the vest he wears. But when the "vamped out" Nick turns around to face the camera, there are no bullet holes in the front of his vest.