Trivia: Hugh Laurie auditioned for the role as Dr. Gregory House in his hotel room bathroom in Namibia. He was rehearsing his role for the film The Flight of the Phoenix and claimed that the bathroom was the only place with enough light. He also apologized for his appearance on tape before the audition as he'd just come back from filming. The fact that House has a somewhat scruffy and unkempt look, particularly his constant five o'clock shadow, has been attributed by creator David Shore to Laurie's appearance in this audition tape.
Trivia: The character of House is based on Sherlock Holmes. Both suffered drug addictions (House - pain killers, Holmes - cocaine). Both focus on the patient/criminal's motives and actions rather than physical evidence. Neither can cope with normal society and have sociable sidekicks (Wilson and Watson - Dr. Wilson actually gets called Dr. Watson once by a patient in the first season). Both are extremely lazy when not on a case (Holmes read the agony aunt columns in the paper, House watches Soaps). Both never call anybody by their first names and finally both live at No 221B.
Trivia: The diagnosis of Lupus appears to be a running joke throughout the series - it is commonly suggested as a possible illness, but is always dismissed. In one episode, House hides his Vicodin in a book on Lupus, stating that 'it is never Lupus'. In another episode House has a janitor stand in for his three assistants (who left at the end of season 3). The janitor suggests Lupus as a possible diagnosis - inevitably he is wrong.