Continuity mistake: In the scene where Rube shakes hands with the animal protesters, he is not wearing the trash bag while shaking their hands. He is wearing the trash bag immediately before and after.
Plot hole: People who do not have their souls retrieved, before they are killed, will suffer the effects of the death on their soul, eg. the autopsied man has scars and cuts on his soul. So how come the woman who was crushed by a piano (whose soul was only ever retrieved afterwards) is unharmed in soul form?
Other mistake: When Rube is searching the hard-copy (paper) archives, the young man with him opens the last box and pulls out an old "Wanted" poster with Rube's face on it. He tells Rube "This guy looks just like you." Since season 1, episode 1, we've known that Grim Reapers don't look like they did when they were alive (i.e., Millie/Un-George). Yet somehow, Rube has not changed since his life/death.
Plot hole: Dead Like Me: Life After Death DVD movie: When he's robbing the grocery store, we see Mason from the point of view of the security camera. We see the Mason that the reapers and the dead see, but we should be seeing the face that is visible to the outside world.
Factual error: Towards the end of the episode, Mason reads a report on Daisy's death indicating she died 13 December 1938 in Marietta Georgia of smoke inhalation. It apparently was common knowledge that Daisy died on the set of Gone with the Wind (supported in the Halloween episode by someone who knew her when she was alive). The filming of the big fire scene in GWTW was 10 December 1938 so the dates are pretty close. But these early parts of the production of GWTW (and I believe the rest of the movie as well) were filmed in Culver City, CA, not Marietta.