Factual error: Gorillas are strict herbivores. So why does Isabelle eat a rat at the beginning of the film? The serum may have turned her into a crazed killer, as it does with Sebastian, but it hasn't changed the structure of her teeth and palate, biochemistry of her digestive system and so on, all of which would be required. She might kill or torture the rat, but she'd never eat it.
Trivia: Whenever Sebastian is invisible and interacting with the other characters, Kevin Bacon's voice would be broadcast throughout several speakers randomly hidden throughout the set. This was done to make the reaction more genuine, since the actors would honestly not know where his voice was going to come from next, just as the characters would not know where Sebastian was.
Trivia: The infamous scene where Sebastian kills a dog was thoroughly investigated by the ASPCA - a non-profit animal welfare advocacy group. They reportedly felt the scene (despite being only shown in heat-vision footage) was so graphic, they suspected it might have been real. Director Paul Verhoeven ended up having to demonstrate how the scene was accomplished - star Kevin Bacon picks up a real dog, but through some slight trickery, was able to quickly switch it out with a realistic fake dog filled with stage-blood when he goes out of frame for about a second.
Trivia: A scene in which Sebastian brutally and graphically rapes his neighbor was filmed, but was mostly deleted as test-audiences felt it made Sebastian far too evil. And thus, the version of the scene in the theatrical cut only alludes to the idea without directly showing it. The original scene was reinstated in the director's cut released on DVD and Blu-Ray however.
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