Factual error: Gorillas are almost exclusively herbivores. They have been observed eating small insects and grubs but nothing larger. So why does Isabelle eat a rat at the beginning of the film? The serum may have turned her into a crazed killer, as it does with Sebastian, but it hasn't changed the structure of her teeth and palate, biochemistry of her digestive system and so on, all of which would be required. She might kill or torture the rat, but she'd never eat it.
Janice: What was the clientele like?
Frank: This guy comes up to me and he says: "l like my women like my coffee."
Janice: People still use that line?
Frank: Maybe he meant cold and bitter.
Janice: Very funny.
Trivia: A scene in which Sebastian brutally and graphically rapes his neighbor was filmed, but was mostly deleted as test-audiences felt it made Sebastian far too evil. And thus, the version of the scene in the theatrical cut only alludes to the idea without directly showing it. The original scene was reinstated in the director's cut released on DVD and Blu-Ray however.
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