Continuity mistake: In the final battle, Jacob turns into a vampire and bites Scott, when Scott hits Jacob with the holy water bomb, Jacob backs away from Scott, when Jacob removes his mouth from Scott's neck, there is no blood on it, two cuts later, there is blood on Scott's neck.
Trivia: When the group of main characters enters the Titty Twister, the barkeeper doesn't want to have them in the bar. The explanation is given in the original screenplay. The barkeeper feared that "normal tourists," unlike bikers and truckers, might be missed by friends or relatives.
Trivia: When the Gecko brothers are at the hotel and George Clooney returns, the bag of food he's holding is from Kahuna Burger, the burger joint talked about by Samuel L Jackson in Quentin Tarentinos other movie, Pulp Fiction.
Carlos: What? Were they psychos, or...? Seth Gecko: They look like psychos? Is that what they looked like? They were vampires. Psychos do not explode when sunlight hits 'em. I don't give a fuck how crazy they are!