Factual error: SPOILER: Amy Dunne returns covered with blood. After being at the hospital, and in the interview/questioning, she is still covered with blood. After being medically examined, she would have been washed clean, not just dressed over all the mess. But it gets worse; when returning to Nick in their house, she has a crisp hospital garment, but is still covered in blood! And it gets even worse; when they are in the shower, the blood on her body, which by now would have been at least a day old, would have been dried, caked and brownish color, but what she washes off is very fresh.Michael Ebner
Continuity mistake: Some scenes were shot after Rosamund Pike had gained some weight, following the plot of the book correctly. However, they were edited together very badly, so that the extra pounds (most visible on her face) come and go several times during the montage showing what she did during the first two days of her "kidnapping." Pasty face with puffy cheeks, and sleek face with taut skin over jutting cheekbones switch back and forth in what amounts to a matter of hours in the film's plot.
Trivia: Tyler Perry was reportedly not aware of director David Fincher's body of work, and was cast without knowing Fincher was directing. Perry has stated that he likely wouldn't have taken the role if he knew about the darker work Fincher is generally involved in, but stated that he was glad he did take the role in the end.