Continuity mistake: Level 12 "Grand Theft Scratchy" cutscene: When Marge tells Poochie that even he isn't "extreme enough to resist the power of a stay-at-home mom, with too much time on her hands, " Poochie is wearing two bracelets, but next shot both bracelets have vanished, then continues to reappear (even within the same shot) and disappear again.
Continuity mistake: Mob Rules: When Martin runs into the road and tells Ned to stop his car, there are two white lines across the road in front of the car. After Martin drives off, the two white lines across the road have suddenly vanished.
Continuity mistake: Enter the Cheatrix: When Bart and Lisa are first in the Game Engine, they are standing side by side on two different sections of the floor. From a reverse angle, they are suddenly standing on the exact same section of the floor.
Continuity mistake: Bartman Begins: When Bart first discovers The Simpsons Game manual, the manual lands in a 12 o'clock direction in front of Bart. Next shot, the manual has shifted to a 9 o'clock direction, then to an 11 o'clock direction.
Continuity mistake: Big Super Happy Fun Fun Game: The first part of the level consists of Homer and Lisa defeating the Dirt Sumos. But as soon as the cut scene starts, all of the sumos have vanished. Even the ones that weren't defeated.
Continuity mistake: Level 10 "Bargain Bin" cutscene: When the alien mothership hovers over the Simpson house, the green door mat is on the step in front of the door, but when Homer freaks out the green mat has vanished, though it reappears when they start running.
Continuity mistake: Level 13 "Medal of Homer" cutscene: Right before Homer receives the keycard, when the military truck drives into the village, in this shot the "Hellfish" illustration on the door is reversed and "Hellfish" is written backwards, then it's fine in the following shots.
Continuity mistake: Level 14 "Big Super Happy Fun Fun Game" cutscene: When Milhouse hands over the keycard to Homer, he's holding it out upside-down, but in the next shot the keycard is rightside-up while he's still holding it out to Homer, but it's upside-down again when Homer takes it.
Continuity mistake: Level 15 "Five Characters in Search of an Author" cutscene: When Marge and her family walk over to Matt Groening, who's lying on the floor, we see that Marge has nothing on her back, but when Matt thanks Marge for saving him the empty baby carrier is now on Marge's back, though it vanishes again when Matt kneels in front of Lisa. As an aside, the baby carrier has two shoulder straps and a waist strap, but after Matt's escape when the carrier reappears on Marge the shoulder straps are gone, so it's pretty bizarre that Maggie could stay put in it.
Continuity mistake: Bargain Bin: When the mothership starts firing at the Simpsons, Homer drops the clipboard and pencil he was holding and it lands on the ground. Two shots after, the clipboard and pencil have disappeared. It couldn't have been out-of-frame because when it lands on the ground, it is in line with the path leading to the house, and the area surrounding the path is shown two shots after.
Continuity mistake: Enter the Cheatrix: When Bart and Lisa walk up to the Rift Portal after saving Frink, the device attached to the side of it changes design between shots.
Continuity mistake: Enter the Cheatrix: There is a machine next to Bart, Lisa and Frink when they reunite in the end cutscene. This machine has three sections to it. When the shot cuts to Bart and Lisa, all three sections of the machine are visible in the shot, but Frink cannot be seen in the shot. Then the shot cuts to Frink (with all three sections of the machine being visible in the shot), and Bart and Lisa cannot be seen even though they should be right next to it.
Continuity mistake: Enter the Cheatrix: When Bart and Lisa walk up to Professor Frink whilst he is climbing down the ladder, the machine next to them has a couple of dials on them. Around these dials are a series of small lines (presumably a way of measuring different gauges). When the shot cuts to focus on Bart and Lisa, these lines around the dials have disappeared. A small arrow attached to the dials also disappears.
Continuity mistake: Game Over: Whilst God is explaining the Planet Earth game to the Simpsons, Maggie's face has light cast on it. But later in the cutscene, after the flashback of God losing the manual, Maggie's face is suddenly shadowed.
Continuity mistake: Game Over: When Homer tells God "It's time for some answers", his hands are raised and placed against each other. When the shot cuts, his hands are at his side.
Continuity mistake: Game Over: When Benjamin Franklin is telling Lisa she's a bigger butt-kisser than Thomas Jefferson, he is holding a coffee cup with his hand at the bottom of the cup. Two shots later, his hand is suddenly further up the cup.
Continuity mistake: Bartman Begins: When Homer asks Bart "what's with the broody get up", there are three buildings shown in the background to the right of shot. A couple seconds later, when Homer and Bart open up the manhole cover, there is now only one large building.
Continuity mistake: Game Over: When Shakespeare says "Stand and unfold yourself", he is holding a quill in his left hand. The way the quill is held changes between shots.
Continuity mistake: Game Over: In the first wide shot of heaven, when the gates close, the shadows of the gates are shown on the ground behind it. When the shot cuts, the shadows are suddenly in front of it.
Continuity mistake: Game Over: When Lisa is using her Buddha hand powers to build the stairway to heaven, one of the buildings she uses is the Springfield Mall. In the shot of the mall being lifted, the area surrounding it has completely changed from when it was last seen in "Invasion of the Yokel Snatchers." A light blue building called Hailstone's has appeared which was a dark blue building when shown earlier, and the shrubbery is completely different.