Factual error: During the "skull monologue", Calvin Candie mentions "genes". The word was coined after 1905 from the work of Danish scientist Wilhelm Ludvig Johannsen. Genetics were born with Mendel's work, which was published in 1866 and did not become widely known in the scientific community until decades later.
Factual error: At the end of the movie, Django has a bundle of dynamite strapped to the front doorframe of Candie's house and uses it to blow up the place. The explosion caused by that bundle was way too large compared to the amount of dynamite used. It also shows the house exploding from the center out, distributing debris almost equally in all directions. But the dynamite was at the front door so most of it would have gone backwards.
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