Continuity mistake: When Rango was at the mayor's office, the mayor grabs out a jug of water, and he opens the lid. But in the next shot, the lid is sealed again.
Continuity mistake: The one arm on the doll is on the right side in the opening scene. After Rango falls out of the car, it has switched to the left. At the end of the movie, it is back on the right.
Continuity mistake: Around the beginning of the movie, when Rango is called by the armadillo, he's shocked and drops the glass in his hand, followed by the breaking sound, but as the scene continues, the shattered glass is nowhere on the road.
Factual error: The 'Mayor' says he's a Turtle, but he's actually a Tortoise. Turtles have paddle type limbs for swimming, not reptile like paws as depicted in the movie.