Deliberate mistake: There was no possible way for Edith to still be alive after the spiked coffin closed in on her. There are spikes on the doors and at the very back and sides of it, and she couldn't have squeezed in to brace herself. Probably done for obvious reasons, but still a mistake nonetheless.
Audio problem: After Gru has unveiled his plan to steal the moon, he says,"That's what I'm talkin' 'bout!" The animation of his mouth, however, includes the unpronounced "a" in the word "about." (00:11:35)
Continuity mistake: When the girls are trapped in Vector's glass bubble, Margo's sweater changes from having rolled up sleeves to normal. Especially visible when the bubble smashes.
Continuity mistake: During one of Gru's attempts to break into Vector's house, he is targeted with many bombs. In the first shot, only one of the bombs is colored red on the end. In the next shot, at least half of the bombs are colored red on the end.
Continuity mistake: Gru drops the bag with the muffin in just before his video call. The bag and muffin disappear instantly. (00:06:30)
Continuity mistake: When Gru is explaining his plan to the minions, one of them takes out a torpedo and fires. The torpedo is held by one of the taller minions at first, but after the torpedo has fired and Gru says "Hey, Dave", we can see the torpedo was held by one of the smaller minions.
Suggested correction: The minion holding the torpedo was a small one all along. The taller one is probably just one in the crowd. If you look closely when the minions grab their weapons, Dave, the one who held it in the first place, is a short minion holding a torpedo.
Continuity mistake: The tourist van drives past an Egyptian man. Every other shot that shows the desert in the background shows no sign of the Egyptian man. Not even a sign of him walking back the way he came.
Continuity mistake: In the scene where Gru steals the shrink ray, his minion puts it in a glass thing. The minion doesn't close the glass door on it, but when it shows Gru and his other minion laughing for victory, the glass door is closed. And the minion didn't have enough time to close the glass container thing.
Continuity mistake: In the scene where Gru goes to get Agnes, Margo, and Edith from Vector from his "lair" (after giving him the moon) he puts his face against the camera and it displays Gru as taking up the full screen. When he then punches the camera it shows only a small portion of the screen is taken up.
Continuity mistake: When Margo is reading out Vector's cookie order to Vector, Edith and Agnes are seen putting the last six boxes of cookies on the table. The cookies aren't there in the next shot.
Continuity mistake: Gru enters the Bank of Evil and starts walking through a corridor. As he starts to walk, he begins to walk past the first pillar. In the next shot, he has suddenly walked past at least 3 pillars.
Other mistake: While Gru is shrinking the moon the camera revolves quickly around the moon as it shrinks. When it cuts to the minions watching from earth, they have the same perspective as us.
Other mistake: The laptop used by Mr Perkins, boss at the Bank of Evil, has two W keys; the second key is between Z and X on the bottom row. (00:56:04)
Continuity mistake: When Gru takes the girls to his house just after adopting them, there is a newspaper on his lawn, lying completely on the grass. In the next shot, part of it is on the dirt pathway.
Continuity mistake: When Gru is hit by all of the missiles and guns that pop out of Vector's fortress he is standing right outside the large door, but in the next shot after he emerges from the crater he is in the middle of the street.
Continuity mistake: When Mr. Perkins is looking at a picture of him and Vector, he sets the picture frame down. In a few shots, the frame disappears.
Continuity mistake: Edith disintegrates Agnes's unicorn and a pile of ashes is left on the ground. In two shots, the pile of ashes moves slightly further from Agnes.
Continuity mistake: After Dr. Nefario uses the fart gun on a minion, the minion falls off the table after being knocked out. Several shots later, the minion is gone without getting up and moving.
Continuity mistake: When Gru gets shot with all those guns at the end of his attempts to get in Vector's house before he first sees the girls, his goggles are at the top of his head. After he gets shot, the dust is not over his eyes, indicating that his goggles were over his eyes, shielding them from the dust.
