Revealing mistake: When Paul goes through Annie's scrapbook, a fast reader may notice that several newspaper clippings (although having different headlines and being based on separate events), have the exact same story underneath. The text has simply been repeated, rather than a new report being created for each story.
Continuity mistake: When Buster and his wife Virginia, first get in their 4x4 truck to head down the road, they discover that broken tree limb. Before he yells "stop!", the only part of the road not covered in snow is the tire tracks. After he walks back up the hill (and Annie drives by), the road has no snow on it.
Continuity mistake: Early in the movie there is a closeup of the typewriter as Paul is writing an early chapter in his Misery book for Anne. In one of the final scenes, as Paul is finishing the last chapter, there is a closeup of the typewriter. It is the exact same text as was written early in the movie, even the word "and" without the "n."
Continuity mistake: When Paul hops out of bed after Annie yells at him for killing Misery, you can see his legs move in the braces several times, even though they should be immobile.
Continuity mistake: When the two main characters are having dinner together, the food on the plates varies in the amount that is eaten - a lot is gone, and then the original amount of food is back again. A bun on the table also goes through this obvious splicing of different takes, and moves around the table, seemingly unaided.
Continuity mistake: When Annie and Paul are having dinner together, Paul pours her a glass of wine. As he is doing so, a few drops spill on the cloth covering the table. The camera then cuts to Annie. As it cuts back to Paul, the few drops of spilt wine are gone. Later, they come back.
Deliberate mistake: Kathy Bates gives James Caan his Noveril a number of times, but one particular time Kathy gives him his Noveril and leaves the room. When the camera shows James Caan holding the capsules between his thumbs and forefingers, it is apparent that they are not James Caan's hands in this shot.
Continuity mistake: After Paul burns the manuscript on the grill, Annie begins to take it out of the room after pouring water on it. In the shot in the room, the grill is smoking, but in the shot from the doorway, the papers have suddenly stopped smoking and there is no smoke anywhere else in the room.
Continuity mistake: In the scene where Paul falls down the basement stairs we see a shot with a case of "Canadian" beer behind his head. In another shot the case is covered up with a blanket.