Trivia: Not a mistake, but something I just noticed on about the 5th viewing. In the very creepy 'I've given very serious thought...to eating your wife' bit, during the ominous pause in the middle a fly crawls down the back/side of Anthony Hopkins' head, then flies around a bit. Can't be helped, and barely noticable, but it does wreck the mood a bit.
Trivia: "The Silence of the Lambs" director Jonathan Demme was approached to direct and had expressed interest in directing a sequel for some time before the publication of the novel. However, he opted not to return, feeling the novel was too gory and excessive compared to "Silence..." and he didn't feel it would make a good film. Producer Dino de Laurentiis also suggested that Demme was also nervous to make a sequel, given the first film's reputation as potentially one of the greatest films ever made. "Silence of the Lambs" star Jodie Foster also refused to return, feeling the character of Clarice Starling was "betrayed" in the novel of "Hannibal."