Continuity mistake: When the Depelter Turbo is used to capture Gladys, Dwayne and Vincent, the beam of light that goes straight up shows us that is is coming from a city (Chicago, perhaps?)just south of the tip of Lake Michigan. However, when RJ opens the bag of tortillas, the orange mushroom cloud shows his location as being farther to the west and south.
Continuity mistake: In the scene where Gladys (the president of the Homeowners' Association), the exterminator man, and the bear are being hurt by the contraband contraptions designed to exterminate the animals, a bright light develops, and the animals watching have to put sunglasses on. When the light disappears, Verne and RJ have tan lines everywhere except where their glasses were. But in the next shot of the animals (they're celebrating), Verne and RJ's tan lines have disappeared.
Factual error: In the beginning when the animals are waking up from hibernation, it shows Ozzie and Heather running out of the log, which shows they hibernated, but opossums don't hibernate.
Continuity mistake: After the rocket wagon scene, RJ lands on the ground and the red wagon and the blue cooler land next to him. In the next couple of shots, the wagon and cooler are further away from RJ.
Continuity mistake: The signs for the fast food places seen when RJ says "foooooood" are not there when we see the first wide shot of the neighborhood earlier in the day.