Plot hole: The first time David werewolfizes, he's reading a book in the brightly lit apartment. Exterior shots of the full moon show it's nighttime out, so the lights inside the apartment must be on. But when Dr. Hirsch calls to check on him, the shot is of the phone ringing, unanswered, in the completely darkened apartment. That's considerate, David. Even as a werewolf, he must have run around turning lights off before going on his rampage.
Continuity mistake: In the scene where David (as a werewolf) exits the theatre, causing general havoc and mayhem, a car crashes into the one in front of it, sending the "driver" through the windshield. If you watch closely (or use slo-mo), you'll see that the driver goes through the windshield just before hitting the car in front of him (or her).
Alex: David, please be rational. Let's go and see Dr. Hirsch.
David: Yeah, be rational. Sure. I'm a fucking werewolf, for Christ's sake.
Trivia: John Landis wanted to use Cat Stevens song Moon Shadow for the opening credits. Cat Stevens refused because he believes werewolves actually exist.
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