Fantastic Voyage (1966)

Plot hole: Even if the white blood cells will attack and destroy the sub and the body of doctor Martin the atoms would still remain and take normal size after the critical 1 hour is up. This would also apply for the laser gun which they forgot or left behind on purpose.

Plot hole: They extract the crew from the tear duct, it was very close to the brain injury, so why didn't they start from there to begin with?

Plot hole: The sub winds up in the wrong circulatory system because of a fistula, so just extract the sub and re-inject back after the fistula and continue with the original journey.