Fantastic Voyage

Plot hole: Even if the white blood cells will attack and destroy the sub and the body of doctor Martin the atoms would still remain and take normal size after the critical 1 hour is up. This would also apply for the laser gun which they forgot or left behind on purpose.

Other mistake: During the miniaturizing scene the technicians controlling the forklift wore sterile gloves, the nurses assembling the syringe did not.

Revealing mistake: It's painfully apparent that the actors are hung on wires pretending to swim while outside the sub.

Grumpy Scot

Factual error: Proteus refills its air supply in the lungs. The lungs are filled with normal sized oxygen molecules. How are they supposed to breathe them? (In the book, they had a miniaturizer on the sub, but there is nothing in the movie to explain this.)

Grumpy Scot

Revealing mistake: During the miniaturization process after Phase I, the sub has been reduced to coin-size at best. As the techs are beginning Phase II, they roll wheeled equipment by the tiny sub. There is a close-up of the sub pilot looking eye-level with the equipment wheel axle, and a tech's ankle is slightly below the pilot's eye-level. This is an impossible perspective: for the pilot to be eye-level with the wheel axle, the sub would have to be more like a foot in diameter and not coin-size. (00:27:10)

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