Continuity mistake: When Peyton returns to his lab after its destruction, a burnt picture of him and Julie is on the floor. The destroyed picture shows half of Peyton's face missing. After finding a new place to stay, when the picture is put into the scanner, more of Peyton's face is visible. (00:28:10 - 00:30:40)
Continuity mistake: In the opening battle at the warehouse, there is frantic gunfire and battling during the scene. However, after the second car crashed, all of Eddie Black's men are suddenly dead, despite almost all of them being alive just a few seconds earlier.
Continuity mistake: When the power goes out in Peyton's lab (when he figures out the secret of the synthetic skin), the entire lab is still filled with some light. If it was daytime, this would be believable, but it is night outside.
Continuity mistake: At the climax of the movie, in the skyscraper construction site, there is a segment where the villains are swinging large wires with metal hooks to hit Peyton. However, the number of wires swinging through the area changes during the course of the shots, and in fact, they all disappear for a period of time.
Continuity mistake: When Darkman's hand is pinned to the steel beam by the rivet there is no blood. When we see a close up of him trying to pull his hand free, there is now blood coming from the wound. When Strack calls Darkman a freak, Darkman gets angry and the blood from his hand is gone. The next shot of his hand shows blood, as he pulls it free from the rivet.
Continuity mistake: During the dancing freak scene, Peyton holds an iron bar and looks at his reflection on a puddle. He lets go of the bar, which falls on the floor. He then takes his hands to his head, but the reflection on the puddle shows his arms at waist level. Also, in the following shot the iron bar falls on the floor again.