Trivia: The video store you see in this film is director John Waters' actual neighbourhood video store.
Trivia: Director John Waters has a voice-over cameo as the voice of Ted Bundy in the tape that's found.
Trivia: Matthew Lillard plays the titular "Serial Mom's" son. Two years later, he would go on to play one of the serial killers in the famous slasher-satire "Scream."
Trivia: Both Julie Andrews and Susan Sarandon were considered for the titular character.