Trivia: Thrax is like Morpheous from the Matrix trilogy. His black coat, black glasses and he is even voiced by Laurence Fishburne. In his end fight with Osmosis there is a very clear Matrix reference (the bullettime effect).
Trivia: In the widely released version of Osmosis Jones in the background of the opening chase scene, a remix of Foreigner's 'Hot Blooded' plays, but in the VHS release it plays Electric Avenue by Eddy Grant.
Trivia: Originally there was going to be a toy line made for Osmosis Jones, but WB lost faith in the project and canceled their release. Only prototypes of the toys exist today.