Plot hole: It's never explicitly stated or shown that the Thing reproduces with each victim until the movie is nearly over (when Palmer infects Windows). Most viewers figure it out from the context, but it's unclear just when and how the characters themselves have come to this conclusion. This was an inadvertent result of an editing decision and a visual goof: there is a deleted scene in which Blair explains much more directly that the Thing multiplies according to how many victims it takes, and in its place in the final film is a scene containing a computer simulation that director John Carpenter acknowledges was a failed attempt at explaining the organism's life cycle.
Plot hole: As the gun-toting Norseman approaches the buildings, Garry smashes the single-pane window with his handgun. It is inconceivable that the glazing in a structure near the South Pole would be single-pane glass, that could be broken so easily.