A serial killer known as Buffalo Bill is murdering women, and even worse, leaving them partially skinned. FBI guru Jack Crawford enlists trainee Clarice Starling to go to Hannibal Lecter, an infamous serial killer and cannibal himself, in an attempt to get information on Buffalo Bill's identity. Therein, Hannibal and Clarice form a strange "quid pro quo" relationship, in which he offers information on her case in exchange for personal information about herself. In time he leads her closer and closer to the way she catches the serial killer, who has, at this time, kidnapped a senator's daughter, sending the urgency of the case skyrocketing. While in custody to offer information to the senator herself, Hannibal kills two security guards and escapes ingeniously by wearing one of the dead men's faces. Clarice finally realises that Buffalo Bill is skinning the murdered women in order to make himself a woman suit out of real women, and accidentally goes to his house while attempting to get information on his identity. She gets caught in the basement with him in the dark after discovering the senator's daughter alive and shoots and kills him. After the ordeal, she is promoted to FBI agent. She then gets a call from Hannibal Lecter, who is abroad and about to make another kill: His nemesis, the doctor at the prison where he was held for eight years.