Continuity mistake: In the scene in the hangar at Memphis airport, Senator Martin's hair keeps changing in each return shot. (01:02:55)
Continuity mistake: When they find out Lecter is on the elevator, they look down the shaft at him and there is quite a lot of blood on his back, so much that it even reaches down to his belt. However when they open the elevator shaft and the body falls down, there is only a small amount of blood on his back. (01:23:40 - 01:24:50)
Continuity mistake: When Clarice tries to push up the blocked door of the self storage container she puts her gloves on her lap. In the next scene the gloves have disappeared. (00:24:15)
Continuity mistake: At the beginning when Clarice is jogging through the woods, the sweat on her sweatshirt varies from shot to shot.
Continuity mistake: When Clarice is searching the basement, the first door she approaches is hinged on the left and opens towards her. She opens it, and it turns into a door that has the hinges on the right and opens away from her. (01:43:50)
Continuity mistake: While travelling from the post mortem examination, Clarice is in the back seat speaking to her boss. In going back and forth in conversation, her hair changes from being curled up to being curled under, all in one swift change. This is a different style and not done as could be by running your fingers through your hair as the camera cut away. (00:37:45)
Continuity mistake: When Lecter is in the ambulance, wearing another man's face, as the ambulance officer has his back to Lecter, Lecter takes the large dressing off his face and pulls the oxygen mask down, then sits up, but when he does, the oxygen mask would be in the way; it is around his neck, he would have had to pull it over his head to get rid of it, but he didn't do this - the oxygen mask vanishes. (01:25:05)
Continuity mistake: When Lecter is in the Memphis jail cell, trying to escape, there is a shot of him eating the face of Sgt. Pembry, and a nano-second later, you see Lecter trying to completely shove the jail door on him. No way these two events could have transpired so quickly. (01:15:50)
Continuity mistake: When Lecter is about to kill the two cops guarding him, he kicks the cell door preventing one of the cops from entering the cell. Just a moment later he is in front of the guard and there is no metal door in between them.
Continuity mistake: Before Clarice chases Buffalo Bill down the basement steps, she quickly slips off her green overcoat, letting it fall to the floor. (I wasn't able to see if the green/red checked blazer and/or the grey scarf she almost always wore were slipped off at the same time - the view was obstructed by a table.) After Bill is killed, Clarice exits the house and comes down the front steps wearing the green/red checked suit jacket (blazer), but does not have the green overcoat or scarf with her. (01:43:13 - 01:50:17)