Deliberate mistake: When Marge goes offroading to get home there is a grassy field which leads right up into the Simpson driveway. However, in all other episodes there is no grassy field and instead there is a house in the spot where the field would be.
Continuity mistake: In the episode which recalls how Homer and Marge got married, Homer writes a note to Marge on a piece of paper entitled 'From The Pen Of Patty' he SCRIBBLES out Patty's name and writes his own, but when Marge reads the note, 'Patty' only has a single straight line through it. The word "HOMER" also changes.
Continuity mistake: Springy the Olympic spring that Homer makes has 9 coils. Then we see the large version that has many coils, at the Olympics meeting. Homer's original spring is in his hand and now it has many coils also. When it cuts back to the stage, the large spring has few coils, like the very first time we saw Springy.