Continuity mistake: After chasing down Sully, the yellow Porsche is totally wrecked on the left side, until Arnie drives it away, and it's fine.
Continuity mistake: After Gerry gets smacked in the face by the 'broken' suspender clasp, we see the silver clasp land under the dresser. Yet, when he's moaning and lifting his leg to get onto the bed, we can actually see the clasp still intact on the front suspender that came loose, which is dangling right behind him (just look between his legs). Of course, in the next shot, that clasp is gone. Since the silver clasp is one of the plot points, this is bizarre to say the least.
Continuity mistake: When John and Catherine are in the hangar at the runway, the Cessna's tail number is N3035C. When the plane is shown in the air, the number is N3973F. When they land, the tail number has changed back to N3035C.
Continuity mistake: In the bedroom scene the girl is holding a clear cup full of beer. The camera goes off her and when it comes back she is holding a blue cup. The camera goes back off her then on her and the cup is clear again.
Continuity mistake: When Sam is in his bedroom, after he finds the Cube sliver it falls and dramatically burns a hole through the floor into the kitchen. But Sam's bedroom is over the living room (there is nothing on the ground floor below Sam's elevated bathroom, and in the first movie Jazz hides in this open space), and the kitchen is actually located between the den and dining room, at the other end of the house. If they were to follow the actual floor plan of the house, the Cube sliver would have landed in the area of the piano in the living room, but where would the fun have been in that?
Character mistake: Baymax, a healthcare robot, says that his programming includes a database of 10,000 symptoms of disease. Yet, he issues the warning, "After eating, wait one hour before swimming." That warning, often given by parents to their children, has no basis in medical fact. People who do not get cramps after eating will not develop cramps by going swimming after eating: http://www.snopes.com/oldwives/hourwait.asp.
New this month Factual error: In the docking scene where Coop is trying to dock the service module to the partly damaged Endurance, the Endurance is spinning around its center axis. As the ship was damaged around the perimeter it would spin around its new center of mass, that would be off axis. The docking bay itself would revolve around this new axis, making alignment much harder.
Factual error: In the scenes at Kings Cross railway station in London, overhead wires are visible above the train; Kings Cross did not have these until 1975.