Plot hole: When Homer is seen at work in the flashbacks (before Maggie was born), he is at his usual control panel in sector 7-G, but he only began working here when Burns made him safety supervisor in season 1, "Homer's Odyssey". Before Maggie was born he should have been working at the conveyor belt with the carbon rods, where we saw him in the first couple of episodes.
Revealing mistake: In the scene where Marge's coat pocket bursts open, the candy flows onto the floor. However if you look to the right of her some of the candy seems to almost float above the floor. The candy's direction is completely to the right but because of the floor being angled it spreads over one woman who is standing and there is nothing there to support the candy.
Other mistake: When the Simpsons' drives the electaurus off the edge of the harbour, it is shown that the front of the car goes downwards. When it cuts to the interior view with the Simpsons' screaming, the view from the back window is tilting down, suggesting the rear is going down and the front coming up. But in the next shot the car is seen in the water with the front down.
Continuity mistake: After Kirk (Milhouse's dad) drives away from the stadium, Bart and Homer are walking along and you can see the Drink Duff sign right next to the edge of the fence. The next shot of Homer noticing the sign, the sign is further away from the edge of the fence and is smaller.
Audio problem: When Horst is checking the power plant, he sees some radioactive liquid pouring out of the chimney, he says "That shouldn't be" but his mouth doesn't move when he says "be". When he spots the raccoons he speaks but his mouth does not move at all. And at the end when Mr Burns is mocking the German men, Horst says "Burns, stop it." but his mouth doesn't move.
Other mistake: In the scene where the Simpsons are viewing the path of the Corvair's Re-entry, the blip representing the spaceship crosses the entire US from North-West to South-East in about three seconds. This is really impossible, even for something going as fast as a spaceship on re-entry would be.