Dr. Meredith Grey: At some point, you have to make a decision. Boundaries don't keep other people out. They fence you in. Life is messy. That's how we're made. So, you can waste your lives drawing lines. Or you can live your life crossing them. But there are some lines that are way too dangerous to cross.
Several times in this episode, jokes are made about the residents thinking George is gay. Isaiah Washington was later fired for making homophobic remarks about T.R. Knight.