House: As long as you're trying to be good, you can do whatever you want.
Dr. Wilson: And as long as you're not trying, you can say whatever you want.
House: So between us, we can do whatever we want. We can rule the world!
House is playing 'Metroid: Zero Mission' on his Gameboy at various times. The Metroid series does not feature space monkeys, nor are there distinct levels. The sounds coming from the game in the show do not match it in real life, and Samus morphing into a ball is most definitely not a failure state.