Continuity mistake: Before Kara uses her heat vision against Vartox she gets some dust on her suit, then she stands up and the dust is gone.
Continuity mistake: When Cat is on the talk show, the microphone on her collar keeps disappearing and reappearing between shots.
Continuity mistake: When Alex brings donuts to try to convince Kara to come back to the D.E.O., Kara picks up 2 donuts which suddenly change to 1 once she sits down, and then back to 2 a few shots later in a wide shot.
The Adventures of Supergirl - S2-E1
Continuity mistake: When Kara saves the chopper the sun on the floor changes between shots.
Continuity mistake: When Vartox starts to fight Kara the sun changes between shots.
Continuity mistake: When Vartox attacks Kara from behind the background changes in the next shot.
Answer: Yes, s02e22. As Kara leaves her office, she said "go get them, Supergirl" to herself. After season 1, the show switched from a CBS production to a CW production and filming moved from L.A. to Vancouver. Flockhart isn't really a fan of traveling to shoot, and didn't want to be away from her family for so long.
Bishop73