Factual error: In the scene at the race track where they show the virus infecting and destroying cells in the blood stream, they clearly show that it is red blood cells being infected. Viruses, in order to replicate, require the cell's DNA replication machinery. However, mature red blood cells in the circulation no longer possess this machinery since they no longer have a nucleus or DNA. It would therefore be impossible for this virus to replicate.
A scientist named Dr. Nekhorvich (Serbedzija), who is a friend of IMF agent Ethan Hunt (Cruise), who is in Australia, wants him to escort him to Atlanta, which he does. While on the plane something bizarre happens and Ethan kills the scientist. It is then revealed that Ethan is not Ethan but Sean Ambrose (Scott) posing as him. He and his cohorts jump out of the plane and then proceed to crash it into a mountain. The real Ethan is then summoned by his superior for a mission but before undertaking it he is instructed to recruit a woman named Nyah Hall (Newton), who is a thief to help them. He does and goes to meet his boss who tells him about his friend and the crash. He then tells him since Ethan was unavailable he sent another agent Sean Ambrose who like Ethan is a disguise expert. They then conclude that Ambrose was the one who crashed the plane and took what his friend was carrying, which he called Chimera. Ethan's mission is to get it back. He is then told that Nyah is Sean's old girlfriend and that he wants her back. Ethan is hesitant because it seems that the two of them have connected but is convinced that she is their best chance to find Ambrose, so he asks her and she agrees.
Sean Ambrose: In just a few hours you can be assured of going down in history as the typhoid Mary of "Aus." G'day.
Trivia: The delays on the MI:2 shoot cost two of the actors high profile roles: Dougray Scott was replaced by Hugh Jackman in X-Men, and Thandie Newton was set to play Lucy Liu's role in Charlie's Angels, but this shoot ran so long that she didn't want to commit to another 6 month shoot immediately, so pulled out.
Question: Why didn't Ethan just give Nyah one of his guns after she infected herself? She could have easily killed Ambrose and others with a surprise attack since they were more interested in keeping her alive and she wanted Ethan to kill her anyway. She had better odds of surviving that way than the impossible plot that followed. She could have killed everyone but Ambrose and he may have let it happen in order to still have a chance at selling the virus.
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