Trivia: Much has been written about the scene where Bowman enters the air lock without his helmet. Studies done by NASA have shown that humans can survive in vacuum for brief periods if they do not hold their breath. Some have commented that Dave appears to hold his breath before blowing the hatch, but careful study of the scene does not show this, as it seems he is simply grimacing, bracing himself for the coming effort. When the film was first shown in theaters, many of them handed out souvenir booklets which included references to this study.
Other mistake: There is something drastically wrong with the design of the spherical 'Aries' moon shuttle. Some seats and many fixtures are 'upside down' relative to the up-down orientation of the shuttle itself, and we see loose food trays and equipment about the place as if this is routine. But - the shuttle is designed to land on the moon. What happens then? The moon has gravity, remember? There are going to be quite a few very disgruntled people dangling upside down like spiders, and there will be loose gear (and perhaps a stewardess or two) bouncing about all over the place. It is not a matter of stowing loose gear or lying flat on landing - some parts of the shuttle are upside down relative to others, which is why the stewardess has to do that famous 180 degree upside down walk. Whichever way you look at it the shuttle is going to encounter serious problems when it reaches a gravity well, which will occur whenever the engines are fired up, never mind landing on the moon.
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