Factual error: In Derailed, the train that Lucinda and Charles ride is called the "Red Line, to Union Station". The Red line in Chicago does not go to Union Station and the train they are on is a Metra suburban mass transit train. The Red Line is part of the "El" system and is part of the CTA, not Metra.
Plot hole: During the end of the fight scene in the hotel, Charlie gets hold of Dexter's gun. This gun is a Desert Eagle variant that fires either a .357, .44, or a .50AE caliber round. At the close proximity to Laroche that Charlie was, he would have taken his head clean off his shoulders instead of just taking out his eye.
Audio problem: When the cop is telling Charles that he is going to circle the block, in the wide shot, his lips don't match the words. This happens a couple of minutes before Charles dumps the car into the river.