Two fallen angels, Loki and Bartleby, are trying to get back into heaven. However, their method of choice results in the destruction of all human life. A direct descendant of Christ, Bethany, is contacted by Metatron who tells her of the situation. She is the only one that can stop Loki and Bartleby from destroying all humanity. They are helped by Rufus, the thirteenth apostle and by prophets, Jay and Silent Bob. A demon named Azarael is working against them however.
Continuity mistake: When Silent Bob renders the demon disabled by using the anti-odour spray, you see him take the spray out of his coat and spray with his thumb. However, it cuts to a front view, and he is clearly seen using his index finger. It then cuts to Bob's rear, and he is, again, spraying with his thumb.