Continuity mistake: When Silent Bob renders the demon disabled by using the anti-odour spray, you see him take the spray out of his coat and spray with his thumb. However, it cuts to a front view, and he is clearly seen using his index finger. It then cuts to Bob's rear, and he is, again, spraying with his thumb.
Continuity mistake: In the Mooby HQ scene, the CEO tells one of his executives to call security. The executive's hand is right on the phone when Loki throws a knife into it. The movie cuts to a close-up of the phone but the executive's hand is nowhere in sight. It then cuts back and you can see the executive with his hand back on the phone, right before he pulls it away when the phone shorts out.
Continuity mistake: Look carefully when they transport to the Mexican Restaurant. Her night dress is unbuttoned at the top but mysteriously closes in a matter of seconds.