Other mistake: Towards the end of the film, after Snipes beats the crap out of a lot of vampires, Whistler throws Blade's sunglasses to him. They show him throw them in one shot, then in the next shot they show Snipes catching them. But look in the background at Whistler, he doesn't have the glasses, but is moving his arm like he is throwing them. The glasses must have been computer animated, and bad editing contributed to this mistake.
Continuity mistake: In the middle of the film when the Bloodpack gear up ready to go out and into the sewers to find the reapers. Blade and Nyssa are talking at a table, Whistler shouts "hey Blade, give me a hand". In this shot we see Nyssa looking at Blade, but in the following shot she is now looking down and away from Blade.
Continuity mistake: At the end of the film when Reinhardt and Whistler are in a room together, Reinhardt turns and looks at the monitors and mouths "what the f**k?" he turns his head to the side, yet in the following shot his body is side on, and he is looking right at Whistler ready for the punch.
Continuity mistake: When Blade is fighting the henchmen near the end, he lifts the last surviving one into the air and you can see Blade's hand through the henchman's throat and it is obviously a dummy. Then, when he falls backwards, his hand is not on his throat, it is on the henchman's shoulder.
Continuity mistake: In the opening scene, Novak is walking down a corridor with a woman, and when she says, "Where did you get that scar on your chin? " Novak puts his hand to his mouth to cover it when he coughs, but in the shot from the security camera and normal view his hand is not at his mouth.
Other mistake: When Blade is fighting Nomak in the House of Pain, Nomak pulls a steel bar out of the ground and Blade retaliates by drawing his sword. The way he does this however (Blade grabs hilt and the sword magically detaches from his back) would suggest that either the sword wasn't sheathed or he just cut through both the scabbard and his coat.