Trivia: When Gary is first telling Wyatt of his idea to make a woman, Wyatt asks,"What about your girl[friend] in Canada?" a reference to Anthony Michael Hall's character in "The Breakfast Club." In the Breakfast Club when Bender is asking Brian if he is a cherry, Brian says that he had slept with a girl from Canada that he met at Niagara Falls. (00:07:00)
Trivia: When the bikers are leaving the house, a strange looking car is parked outside the house, seen through the hole. This is the same car that was driven by the Humongous in The Road Warrior, complete with the people tied to the posts mounted on it. The leader of the bikers in Weird Science was Vernon Wells, who played the bandit that Mel Gibson met on the road at the beginning of The Road Warrior, and was in pretty much the whole movie after that.
Trivia: Kelly LeBrock was not John Hughes' first choice for Lisa. Originally Kelly Emberg was cast as Lisa when filming began in Chicago. All the mall scenes that included Lisa were shot with Emberg during mall hours. Then two weeks later they returned to the mall to reshoot all the mall scenes, this time with LeBrock as Lisa.