Continuity mistake: Towards the end of the movie when Sherrie's ex punches Big Momma (Martin Lawrence) in the face, he punches her on the left side of her face. But the latex comes off the right side of her face.
Continuity mistake: In the scene where Big Momma's gentleman caller comes to the door, Martin Lawrence runs over to the door and stands directly in front of it with both of his hands up gripping his gun. This can be seen in the shot when we see into the house through the window on the door. In the very next shot both of his hands are down.
Continuity mistake: When Big Momma (Martin Lawrence) is in the place where Nolan supposedly teaches them to defend themselves. When Nolan is looking at Gertrude, you can clearly see a young face, with no wrinkles. Then when she is laying down on the floor, there is a very old face. They used a double for the scene in which she is hit.
Continuity mistake: When Big Momma wakes up to find that his face is peeling off and Shari knocks on the door, Big Momma goes out the window and his whole outfit comes off. He is completely dressed in a T shirt, sweats and tennis shoes. Why would he have clothes on under Big Momma's outfit, it would be too hot.