Worn down and out of luck, aging publisher Will Randall (Jack Nicholson) is at the end of his rope when a younger co-worker (James Spader) snatches both his job and wife out from under his nose. But after being bit by a wolf, Will suddenly finds himself energized, more competitive than ever, and possessed with amazingly heightened senses. Meanwhile, the beautiful daughter of his shrewd boss (Michelle Pfeiffer) begins to fall for him - without realizing that the man she's begun to love is gradually turning into the creature by which he was bit.
Will Randall: What do you do?
Laura: Why do you care?
Will Randall: I don't. I was just making polite conversation.
Laura: I'd rather not discuss what I do.
Will Randall: You know, I think I understand what you're like now. You're very beautiful and you think men are only interested in you because you're beautiful, but you want them to be interested in you because you're you. The problem is, aside from all that beauty, you're not very interesting. You're rude, you're hostile, you're sullen, you're withdrawn. I know you want someone to look past all that at the real person underneath but the only reason anyone would bother to look past all that is because you're beautful. Ironic, isn't it? In an odd way you're your own problem.