Revealing mistake: After being flattened by the steamroller, Judge Doom staggers over to the compressed air tank and reinflates himself. When his black hat pops off, strings can be seen pulling it up. (01:29:45)
Revealing mistake: When Judge Doom gets sprayed by the Dip spraying machine, stunt cables attached to him are visible, pulling him backwards. Christopher Lloyd also seems to have been replaced with a dummy. (01:31:22)
Revealing mistake: After Roger reads Marvin Acme's will out loud, all of the toons start jumping for joy. Meanwhile the music machine is still activated in the background, and its colorful flashing lights are being reflected on the ground near Betty Boop and Tweety at the front of the crowd. With all of the toons grouped together like they are, the machine's colorful lights should have been obscured, not reflected. (01:35:30)
Revealing mistake: When Eddie fires his "Toon" revolver at the whisky bottle, you can see what appears to be a white, plastic model in his hands. This obviously would've been used as a reference for the animation to be tracked onto later.
Revealing mistake: During the climax, one of the weasels says "Toon Town's right on the other side of the wall, boss!" If you look, you can see a brick moving completely by itself behind him. It literally just pushes out of the hole in the wall as though it's being pushed from the other side. It seems like the other weasel was supposed to be animated pulling it out, and they somehow forgot to animate that part. (He does reach over and grab it for a split second... but then immediately lets go for some reason).
Revealing mistake: In some shots with the red cars, such as when Benny, Eddie, and Roger are about to crash into one, look at the wheels. The trucks appear raised with a third, large wheel in the center, obviously a road vehicle outfitted to look like a streetcar.
Answer: There's really a lot of possible reasons he hates other toons. There's a whole Roger Rabbit book and comic book series that explain Doom's background more. In the film, he's greedy and wants to destroy Toon Town to build the freeway to make more money. In human disguise he's also seen as merciless and is just punishing toons to maintain law and order, etc. Although that's just an excuse to kill toons as well. However, not explained in the film; as a toon he was cast as the antagonist in cartoon films until an accident one day left him thinking he was an actual villain (as opposed to just an actor playing one). That's when he began his life of crime, including killing Teddy Valiant. So his hatred of toons is more about him being evil and not a personal vendetta against them, like Blade's motives.